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IMM Institute for Molecular Medicine

Biomedical research, linking basic life science research with a focus on molecular medicine

Health disorders are generally associated with changes at the molecular (biochemical or biophysical) level. At IMM, we conduct research on individual molecules, in the cellular context, and on their impact on cell systems, organs, organisms.

Our goal is biomedical research – combining basic life science research with a focus on molecular medicine.

What we do

Research with a focus on molecular medicine: cellular perception and signal processing, renal physiology, osmosensing, hereditary vascular malformations, protein quality control and related diseases, molecular function and pathophysiology of ion transport processes, cell networks, electrical and molecular properties of nerve cells, optogenetic methods, molecular neurobiology
Translational approach in molecular medicine research to combine molecular research and clinical trials
Development of research modules in teaching – experimental work in the wet laboratory; molecular and cell biological, biochemical and biophysical methods; molecular medical work processes
Offer of internships, theses and doctoral topics; Participation in the ERASMUS programme and graduate schools
Establishment of service units for electrophysiology, cell imaging and biomarker and drug testing

Research

The Institute for Molecular Medicine focuses on biomedical research. The Institute focuses on combining basic research in the life sciences with a focus on molecular medicine. The working groups here cover a wide range of fields, from cellular communication and cell physiology to cellular biochemistry and biophysics, to neuronal diversity and interconnection. A wide range of methods is applied to basic and translational questions. In addition to standard methods of molecular biology, biochemistry and cell biology, these include modern methods. the most advanced biomedical techniques, such as quantitative live cell microscopy and electrophysiological measurements. New methods and cellular models are also being developed for molecular and cellular examination of disease patterns.

Research fields:

Molecular Cell Biology and Biophysics
Molecular and Cellular Neurobiology
Protein biochemistry
Molecular Oncology
Disease models at cell and organ level
Translational approaches

Platforms & Services:

Light microscopy / bioimaging
Confocal Microscopy
Electrophysiology
Cell culture
RNA biochemistry
Gene sequencing
Histopathology
Typical Organ Tissue Models
Measurement of biomarkers (e.g. hormones)

Working groups

Prof. Dr. Chalid Assaf
Chair of Dermatology
Priorities:

Understanding the pathogenesis of cutaneous lymphomas
Identification of new targets for diagnostics and treatment
Evaluation of prognostic biomarkers
Evaluation of new substances for the treatment of cutaneous lymphoma

Prof. Dr. Maike Glitsch
Chair of Physiology
Priorities:

Cellular perception of the environment
pH- and acid-sensitive G-protein coupled receptors in neuronal and non-neuronal cells

Prof. Dr. rer. nat. Markus Kretz
Chair of Biochemistry
Priorities:

Regulation of skin homeostasis and associated diseases
Function and mechanisms of action of non-protein-coding RNAs in healthy and diseased tissues

Prof. Dr. Christoph Küper
Chair of Physiology
Priorities:

Renal physiology
Immune response in urinary tract infections
Osmosensing

Prof. Dr. Heidi Olzscha
Chair of Biochemistry
Priorities:

Protein quality control and proteostasis
Protein folding diseases (proteinopathies), incl. neurodegenerative disorders
Posttranslational modification
Pharmacological action on proteinopathies

Prof. Dr. med. Matthias Rath
Chair of Human Genetics
Priorities:

Molecular Genetic Diagnostics and Genomic Medicine
Pathogenesis of hereditary vascular malformations
iPSC- and organoid-based models of neurovascular diseases

Prof. Dr. Tobias Stauber
Chair of Biochemistry
Priorities:

Biophysics, biochemistry and cell biology of ion and osmolyte transporters
Vesicular ion homeostasis in musculoskeletal and nervous system disorders (e.g. epilepsy, neurodegeneration)

Prof. Dr. Christian Wozny
Chair of Neurophysiology
Priorities:

Electrical, anatomical and molecular properties of different types of nerve cells
Neural Circuits
Biological Psychiatry
Optogenetic methods
Organoids

Dr. Raed Abu Dawud
Postdoc

Molecular and cell biology of pluripotent stem cells, organoids

Dr. Malte Klüssendorf
Postdoc

Molecular cell biology and biochemical regulation of ion transporters, intracellular membrane transport, cellular disease models

Dr. Yulia Kostritskaia
Postdoc

Electrophysiology
Regulation of ion channels in neuronal and non-neuronal cells

Dr. Haijia Wu
Postdoc

protein misfolding, protein quality control, proteinopathies

Dr. rer. nat. Shroddha Bose
PhD student

Cell biology of the autophagosomal/degradative pathway in neuronal
Disorders

Publications

2023

Hadrian K., Musial G., Schönberg A., Georgiev T., Küper C., Bock F., Jantsch, J.; Claus Cursiefen C., Eming S.A., Hos D. The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury. Exp Mol Med. 2023 Mar 3. doi: 10.1038/s12276-023-00954-w. Online ahead of print.

2022

Kuntz T, Siebdrath J, Hofmann SC, Baltaci M, Schaller J, Hellmich M, von Goltzheim LS, Assaf C, Oellig F, Michalowitz AL, Helbig D, Kreuter A. Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers. J Dtsch Dermatol Ges. 2022 Nov 28. doi: 10.1111/ddg.14911. Online ahead of print.

Webster JF, Beerens S, Wozny C (2022) Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula. Neuropsychopharmacology. doi: 10.1038/s41386-022-01493-0.

Michalowitz AL, Burmann SN, Oellig F, Assaf C, Cerroni L, Kreuter A.Bendamustine monochemotherapy in aggressive or advanced-stage primary cutaneous T-cell lymphomas. J Eur Acad Dermatol Venereol. 2022 Oct 26. doi: 10.1111/jdv.18691. Online ahead of print.

Felbor U, Bülow R, Schmutzler RK, Rath M. Hereditary Breast and Ovarian Cancer Service in Sparsely Populated Western Pomerania. Healthcare (Basel). 2022 Oct 13; 10(10). doi:10.3390/healthcare10102021.

Oymanns M, Daum-Marzian M, Bellm A, Elsayad K, Eich HT, Assaf C. Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced CTCL. Br J Dermatol. 2022 Oct 20. doi.org/10.1093/bjd/ljac012

He H, Stauber T, Liao W, Jiang Y, Yu Y, Peng J. Editorial: Ion channels and transporters in epilepsy: From genes and mechanisms to disease-targeted therapies. Front Mol Neurosci. 2022 Sep 21;15:1011843. doi: 10.3389/fnmol.2022.1011843.

Langrich T, Bork K, Horstkorte R, Weber V, Hofmann B, Fuszard M, Olzscha H (2022) Disturbance of Key Cellular Subproteomes upon Propofol Treatment Is Associated with Increased Permeability of the Blood-Brain Barrier. Proteomes. doi: 10.3390/proteomes10030028.

Blazejak C, Stranzenbach R, Gosman J, Gambichler T, Wehkamp U, Stendel S, Klemke CD, Wobser M, Olk J, Nicolay JP, Weyermann M, Stadler R, Assaf C. Clinical Outcomes of Advanced-Stage Cutaneous Lymphoma under Low-Dose Gemcitabine Treatment: Real-Life Data from the German Cutaneous Lymphoma Network. Dermatology. 2022;238(3):498-506.

Querfeld C, Scarisbrick JJ, Assaf C, Guenova E, Bagot M, Ortiz-Romero PL, Quaglino P, Bonizzoni E, Hodak E. Post hoc Analysis of a Randomized, Controlled, Phase 2 Study to Assess Response Rates with Chlormethine/Mechlorethamine Gel in Patients with Stage IA-IIA Mycosis Fungoides. Dermatology. 2022;238(2):347-357

Assaf C, Dobos G. New treatment concepts and combination therapies for cutaneous T-cell lymphomas Dermatologie (Heidelb). 2022 Sep 8. doi: 10.1007/s00105-022-05053-x.

Pilz RA, Skowronek D, Hamed M, Weise A, Mangold E, Radbruch A, Pietsch T, Felbor U, Rath M. Using CRISPR/Cas9 genome editing in human iPSCs for deciphering the pathogenicity of a novel CCM1 transcription start site deletion. Front Mol Biosci. 2022 Aug 25; 9:953048. doi:10.3389/fmolb.2022.953048.

Model MA, Hassani Nia F, Zook E, Hollembeak JE, Stauber T. Uptake of Fluorescein upon Osmotic Cell Swelling is Dependent on the Volume-Regulated Anion Channel VRAC/LRRC8. PPExMed 2022;1:3-14. doi: 10.33594/000000533.

Shoubash L, Baldauf J, Matthes M, Kirsch M, Rath M, Felbor U, Schroeder HWS. Long-term outcome and quality of life after CNS cavernoma resection: eloquent vs. non-eloquent areas. Neurosurg Rev. 2022 Jun 23; 45(1):649-660. doi:10.1007/s10143-021-01572-8.

Rath M*, Schwefel K*, Malinverno M, Skowronek D, Leopoldi A, Pilz RA, Biedenweg D, Bekeschus S, Penninger JM, Dejana E, Felbor U. Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells. Cell Mol Life Sci. 2022 Jun 4; 79(6):340. doi:10.1007/s00018-022-04355-6. * equal contribution

Reichelt-Wurm S, Pregler M, Wirtz T, Kretz M, Holler K, Banas B, Banas MC. The Interplay of NEAT1 and miR-339-5p Influences on Mesangial Gene Expression and Function in Various Diabetic-Associated Injury Models. Noncoding RNA. 2022. 8(4), 52.

Assaf C, Dobos G, Zech IM, Doess A, Hibbe T, Jadasz JJ. Care structure of patients with mycosis fungoides and Sézary syndrome in Germany - Care research based on SHI claims data. J Dtsch Dermatol Ges. 2022 May;20(5):643-651. doi: 10.1111/ddg.14725.

Assaf C, Booken N, Dippel E, Guenova E, Jonak C, Klemke CD, Nicolay JP, Schlaak M, Wobser M, Trautinger F. The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region). J Dtsch Dermatol Ges. 2022 May;20(5):579-586. doi: 10.1111/ddg.14688.

Beerens S, Winterer J, Lukacsovich D, Földy C, Wozny C. Transcriptomically-Guided Pharmacological Experiments in Neocortical and Hippocampal NPY-Positive GABAergic Interneurons. eNeuro. 2022 Apr 25;9(2):ENEURO.0005-22.2022. doi: 10.1523/ENEURO.0005-22.2022.

Dippel E, Assaf C, Becker JC, von Bergwelt-Baildon M, Bernreiter S, Cozzio A, Eich HT, Elsayad K, Follmann M, Grabbe S, Hillen U, Klapper W, Klemke CD, Loquai C, Meiss F, Mitteldorf C, Wehkamp U, Nashan D, Nicolay JP, Oschlies I, Schlaak M, Stranzenbach R, Moritz R, Stoll C, Vag T, Weichenthal M, Wobser M, Stadler R. S2k-Guidelines - Cutaneous lymphomas (ICD10 C82 - C86): Update 2021. J Dtsch Dermatol Ges. 2022 Apr;20(4):537-554.

Nawar T, Elsayad K, Müller EC, Rolf D, Moritz RKC, Bormann E, Weishaupt C, Stranzenbach R, Stadler R, Moustakis C, Assaf C, Livingstone E, Sunderkötter C, Steinbrink K, Eich HT. Quality of life in patients with mycosis fungoides and Sézary syndrome undergoing low-dose total skin electron beam therapy with or without maintenance therapy. J Am Acad Dermatol. 2022 Apr;86(4):889-891

Byrne AB, Brouillard P, Sutton DL, …, Rath M, …, Vikkula M, Scott HS, Harvey NL. Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Sci Transl Med. 2022 Mar 2; 14(634):eabm4869. doi:10.1126/scitranslmed.abm4869.

Dobos G, Assaf C. Transcriptomic changes during stage progression of mycosis fungoides: from translational analyses to their potential clinical implications. Br J Dermatol. 2022 Mar;186(3):387-388
Moudio S, Willis A, Pytka K, Abulkassim R, Brett RR, Webster JF, Wozny C, Barbour M, Jiang HR, Watson DG, van Kralingen JC, MacKenzie SM, Daniels M, McColl BW, Sossick S, Nuthall HN, Bushell TJ. Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology (Berl). 2022 Jan;239(1):229-242. doi: 10.1007/s00213-021-06040-1.

2021

Chen L, Hassani Nia F, Stauber T. Ion Channels and Transporters in Muscle Cell Differentiation. Int J Mol Sci. 2021 Dec 19;22(24):13615. doi: 10.3390/ijms222413615.

Assaf C, Waser N, Bagot M, He M, Li T, Dalal M, Gavini F, Trinchese F, Zomas A, Little M, Pimpinelli N, Ortiz-Romero PL, Illidge TM. Contemporary Treatment Patterns and Response in Relapsed/Refractory Cutaneous T-Cell Lymphoma (CTCL) across Five European Countries. Cancers 2021 Dec 29;14(1):145.

Webster JF, Lecca S, Wozny C. Inhibition Within the Lateral Habenula-Implications for Affective Disorders. Front Behav Neurosci. 2021 Nov 26;15:786011. doi: 10.3389/fnbeh.2021.786011. PMID: 34899206.

Kolobkova Y, Pervaiz S, Stauber T. The expanding toolbox to study the LRRC8-formed volume-regulated anion channel VRAC. Curr Top Membr. 2021;88:119-163. doi: 10.1016/bs.ctm.2021.10.001.

Pfirrmann T, Chondrogianni N, Olzscha H, Vasilaki A. Editorial: Dysregulated Protein Homeostasis in the Aging Organism. Front Mol Biosci. 2021 Oct 14;8:788118. doi: 10.3389/fmolb.2021.788118.

Zimmer L, Livingstone E, Krackhardt A, Schultz ES, Göppner D, Assaf C, Trebing D, Stelter K, Windemuth-Kieselbach C, Ugurel S, Schadendorf D. Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAFV600 mutant melanoma: safety and tolerability results from the phase I IMMU-TARGET trial. Eur J Cancer. 2021 Oct 13;158:72-84

Liang HC, Costanza M, Prutsch N, …, Assaf C, Knörr F, Damm-Welk C, Woessmann W, Turner SD, Look AT, Mathas S, Kenner L, Merkel O. Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nat Commun. 2021 Sep 22;12(1):5577

Rössler U, Hennig AF, Stelzer N, Bose S, Kopp J, Søe K, Cyganek L, Zifarelli G, Ali S, von der Hagen M, Strässler ET, Hahn G, Pusch M, Stauber T, Izsvák Z, Gossen M, Stachelscheid H, Kornak U. Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis. J Bone Miner Res. 2021 Aug;36(8):1621-1635. doi: 10.1002/jbmr.4322.

Much CD, Sendtner BS, Schwefel K, Freund E, Bekeschus S, Otto O, Pagenstecher A, Felbor U, Rath M, Spiegler S. Inactivation of Cerebral Cavernous Malformation Genes Results in Accumulation of von Willebrand Factor and Redistribution of Weibel-Palade Bodies in Endothelial Cells. Front Mol Biosci. 2021 Jul 9; 8:622547. doi:10.3389/fmolb.2021.622547.

Beerens S, Vroman R, Webster JF, Wozny C. Probing subicular inputs to the medial prefrontal cortex. iScience. 2021 Jul 10;24(8):102856. doi: 10.1016/j.isci.2021.102856.

He H, Guzman RE, Cao D, Sierra-Marquez J, Yin F, Fahlke C, Peng J, Stauber T. The molecular and phenotypic spectrum of CLCN4-related epilepsy. Epilepsia. 2021 Jun;62(6):1401-1415. doi: 10.1111/epi.16906.

Webster JF, Vroman R, Beerens S, Sakata S, Wozny C. NDNF is selectively expressed by neocortical, but not habenular neurogliaform cells. Eur J Neurosci. 2021 Jun;53(11):3561-3575. doi: 10.1111/ejn.15237.

He H, Cao X, Yin F, Wu T, Stauber T, Peng J. West Syndrome Caused By a Chloride/Proton Exchange-Uncoupling CLCN6 Mutation Related to Autophagic-Lysosomal Dysfunction. Mol Neurobiol. 2021 Jun;58(6):2990-2999. doi: 10.1007/s12035-021-02291-3.

Riemer J, Panfilova D, Olzscha H. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases. Proteostasis and Proteolysis CRC Press, 2021, 276 pp.

Assaf C. Cancer-Associated Fibroblasts Play an Important Role in Early-Stage Mycosis Fungoides. J Invest Dermatol. 2021 Mar;141(3):479-480

Bose S, He H, Stauber T. Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters. Front Cell Dev Biol. 2021 Feb 23;9:639231. doi: 10.3389/fcell.2021.639231.
Wehkamp U, Mitteldorf C, Stendel S, Stranzenbach R, Nicolay JP, Wobser M, Weichenthal M, Schneiderbauer R, Klemke CD, Hillen U, Kempf W, Assaf C. Most rare subtypes of cutaneous lymphoma display variable CD30 expression: analysis of the German Cutaneous Lymphoma Network. Br J Dermatol. 2021 Jan 22. doi: 10.1111/bjd.19823.

2020

Yuste R, …, Wozny C, Wuttke TV, Yong L, Yuan J, Zeng H, Lein E. A community-based transcriptomics classification and nomenclature of neocortical cell types. Nat Neurosci. 2020 Dec;23(12):1456-1468. doi: 10.1038/s41593-020-0685-8.

Weber V, Olzscha H, Längrich T, Hartmann C, Jung M, Hofmann B, Horstkorte R, Bork K. Glycation Increases the Risk of Microbial Traversal through an Endothelial Model of the Human Blood-Brain Barrier after Use of Anesthetics. J Clin Med. 2020 Nov 16;9(11):3672. doi: 10.3390/jcm9113672.

Chen L, König B, Stauber T. LRRC8 channel activation and reduction in cytosolic chloride concentration during early differentiation of C2C12 myoblasts. Biochem Biophys Res Commun. 2020 Nov 12;532(3):482-488. doi: 10.1016/j.bbrc.2020.08.080.

Knobler R, Arenberger P, Arun A, Assaf C, Bagot M, Berlin G, Bohbot A, Calzavara-Pinton P, Child F, et al. European dermatology forum - updated guidelines on the use of extracorporeal photopheresis 2020 - part 1. J Eur Acad Dermatol Venereol. 2020 Oct 6. doi: 10.1111/jdv.16890. Online ahead of print

Knobler R, Arenberger P, Arun A, Assaf C, Bagot M, Berlin G, Bohbot A, Calzavara-Pinton P, Child F, et al. European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2. J Eur Acad Dermatol Venereol. 2020 Sep 22. doi: 10.1111/jdv.16889. Online ahead of print

Grosser S, Buck N, Braunewell KH, Gilling KE, Wozny C, Fidzinski P, Behr J. Loss of Long-Term Potentiation at Hippocampal Output Synapses in Experimental Temporal Lobe Epilepsy. Front Mol Neurosci. 2020 Aug 28;13:143. doi: 10.3389/fnmol.2020.00143.

Webster JF, Wozny C. Behavior: Local Lateral Habenula Interneurons Mediate Aggression. Curr Biol. 2020 Aug 17;30(16):R954-R956. doi: 10.1016/j.cub.2020.06.065.

Schwefel K, Spiegler S, Kirchmaier BC, Dellweg PKE, Much CD, Pané-Farré J, Strom TM, Riedel K, Felbor U, Rath M. Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3. FASEB J. 2020 Jun 9; 34(7):9018-9033. doi:10.1096/fj.201902888R.

Kulka LAM, Fangmann PV, Panfilova D, Olzscha H. Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease. Front Cell Dev Biol. 2020 Jun 3;8:425. doi: 10.3389/fcell.2020.00425.

Webster JF, Vroman R, Balueva K, Wulff P, Sakata S, Wozny C. Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula. Sci Rep. 2020 May 22;10(1):8490. doi: 10.1038/s41598-020-65349-7.

Glitsch MD. Helix 8 - Putting a spring in mechano-sensing. Cell Calcium. 2020 May;87:102192. doi: 10.1016/j.ceca.2020.102192.

Pilz RA, Schwefel K, Weise A, Liehr T, Demmer P, Spuler A, Spiegler S, Gilberg E, Hübner CA, Felbor U, Rath M. First interchromosomal insertion in a patient with cerebral and spinal cavernous malformations. Sci Rep. 2020 Apr 14; 10(1):6306. doi:10.1038/s41598-020-63337-5.

Skowronek D, Hebebrand M, Erber R, Agaimy A, Zweier C, Felbor U, Rath M. Identification and characterization of a GLMN splice site variant in a family with glomuvenous malformations. Eur J Dermatol. 2020 Apr 1; 30(2):179-181. doi:10.1684/ejd.2020.3716.

Rath M, Pagenstecher A, Hoischen A, Felbor U. Postzygotic mosaicism in cerebral cavernous malformation. J Med Genet. 2020 February 20; 57(3):212-216. doi:10.1136/jmedgenet-2019-106182.

Weber V, Bork K, Horstkorte R, Olzscha H. Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells. J Vis Exp. 2020 Feb 14;(156). doi: 10.3791/60692.

Elsayad K, Kroeger K, Greve B, Moustakis C, Assaf C, Stadler R, Lenz G, Weishaupt C, Eich HT, et al. Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlenther Onkol. 2020 Jan;196(1):77-84.
Graf J, Kretz M. From structure to function: route to understanding lncRNA mechanism. Bioessays, 2020. [Epub].

Ausgewählte Publikationen

Haider A, Steininger A, Ullmann R, Hummel M, Dimitrova L, Beyer M, Vandersee S, Lenze D, Sterry W, Assaf C*, Möbs M*. Inactivation of RUNX3/p46 Promotes Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2016 Nov;136(11):2287-2296.

Humme D, Haider A, Möbs M, Mitsui H, Suárez-Fariñas M, Ohmatsu H, Geilen CI, Eberle J, Krueger JG, Beyer M, Hummel M, Anagnostopoulos I, Sterry W, Assaf C. Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target. J Invest Dermatol. 2015 Sep;135(9):2292-300.

Steininger A, Möbs M, Ullmann R, Köchert K, Kreher S, Anagnostopoulos I, Hummel M, Beyer M, Janz M, Klemke CD, Stein H, Dörken B, Sterry W, Schrock E, Mathas S, Assaf C. Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. J Exp Med. 2011; 208:1585-93.

Wei WC, Bianchi F, Wang YK, Tang MJ, Ye H, Glitsch MD (2018). Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68). Curr Biol 28: 3815-3823.e4.

Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD (2017). Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells. J Physiol 595: 5525-5544.

Wei WC, Jacobs B, Becker EB, Glitsch MD (2015). Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H. Proc Natl Acad Sci 112: 10738-43.

Ziegler C.*, Graf J.*, Faderl S., Schedlbauer J., Strieder N., Förstl B., Spang R., Bruckmann A., Merkl R., Hombach S., Kretz M. The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis. EMBO Rep, 20(2):e46612.

Kretz M., Siprashvili Z.*, Chu C.*, Webster D.E.*, Zehnder A., Lee C.S., Flockhart R.J., Chow J., Johnston D., Groff A.F., Kim G.E., Raj A., Rinn J.L., Chang H.Y., Khavari P.A. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature, 493(7431):231-5.

Kretz M.*, Webster D.E.*, Flockhart R.J., Lee C.S., Zehnder A., Lopez-Pajares V., Qu K., Zheng G. X. Y., Chow J., Kim G. E., Rinn J.L., Chang H.Y., Siprashvili Z., Khavari P.A. (2012). Suppression of progenitor differentiation requires the long non-coding RNA ANCR. Genes Dev, 26(4):338-43.

Küper C, Beck FX, Neuhofer W (2016). Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renal carcinoma cells. Oncol Lett 12: 2201-2209.

Küper C, Beck FX, Neuhofer W (2014). NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells. Front Physiol 5: 293.

Küper C, Beck FX, Neuhofer W (2012). Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells. Am J Physiol Renal Physiol 302: F38-46.

Olzscha H (2019). Posttranslational modifications and proteinopathies: how guardians of the proteome are defeated. Biol Chem 400, 895-915.

Olzscha H, Fedorov O, Kessler BM, Knapp S, La Thangue NB (2017). CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation. Cell Chem Biol 24, 9-23.

Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU, Vabulas RM (2011). Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 144, 67-78.

Rath M*, Schwefel K*, Malinverno M, Skowronek D, Leopoldi A, Pilz RA, Biedenweg D, Bekeschus S, Penninger JM, Dejana E, Felbor U (2022). Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells. Cell Mol Life Sci 79:340. * equal contribution

Schwefel K, Spiegler S, Kirchmaier BC, Dellweg PKE, Much CD, Pané-Farré J, Strom TM, Riedel K, Felbor U, Rath M (2020). Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3. FASEB J 34:9018-9033.

Rath M, Pagenstecher A, Hoischen A, Felbor U (2020). Postzygotic mosaicism in cerebral cavernous malformation. J Med Genet 57:212-216.

König B, Schwartz S, Hao Y, Plested AJ, Stauber T (2019). A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. eLife e45421.

Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014). Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 344: 634-638. | *corresponding authors.

Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T (2011). ClC-7 is a slowly voltage-gated 2Cl^–/1H⁺-exchanger and requires Ostm1 for transport activity. EMBO J 30: 2140-2152.

Wozny C, Beed P, Nitzan N, Pössnecker Y, Rost BR, Schmitz D (2018). VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons. Front Cell Neurosci. 12: 337.

Penn AC*, Balik A*, Wozny C*, Cais O, Greger IH (2012). Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain. Neuron 76: 503-10. | * equal contribution

Wozny C, Williams SR (2011). Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex. Cereb Cortex 21: 1818-26.

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