IMM Institute for Molecular Medicine

The Institute focuses on combining basic and preclinical research in life sciences and molecular medicine. The research groups cover a wide range of fields, from cellular communication and cell physiology to cellular biochemistry and biophysics, to neuronal diversity and interconnection. A wide range of methods is applied to basic and translational questions. In addition to standard methods of molecular biology, biochemistry and cell biology, these include advanced biomedical techniques, including quantitative live cell microscopy, electrophysiological measurements.

Research fields:

• Molecular cell biology and biophysics
• Molecular and cellular neurobiology
• Protein biochemistry
• Molecular oncology
• RNA biochemistry
• Disease models at cell and organ level
• Translational approaches
  
  

Platforms & Services:

• Light microscopy / bioimaging
• Confocal microscopy
• Electrophysiology
• Cell culture
• Gene sequencing
• Histopathology
• Typical organ tissue models
• Measurement of biomarkers

2024

• Kostritskaia Y, Pervaiz S, Klemmer A, Klüssendorf M, Stauber T. Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling. J Physiol in press
• Motiei M, Abu-Dawud R, Relógio A, Assaf C. Circadian Rhythms in Haematological Malignancies: Therapeutic Potential and Personalised Interventions. EBioMedicine in press.
• Elsayad K, Guenova E, Assaf C, Nicolay JP, Trautinger F, Stadler R, Waldstein C, Boterberg T, Meijnders P, Kirova Y, Dobos G, Duque-Santana V, Riggenbach E, Elsheshtawy W, Niezink A, Papadavid E, Scarisbrick J, Vermeer M, Neelis KJ, Bagot M, Battistella M, Quaglino P, Knobler R, Kempf W, Maklad A, Adeberg S, Kouloulias V, Simontacchi G, Corradini S, König L, Eich HT, Cowan R, Correia D. Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group. Eur J Cancer. 212:115064.
• Abdel Tawab R, Rajy J, Abdallat S, Almurrawi MA, Al Farsi K, Alassaf J, Alhateeti H, Al Lafi A, El Bahtimi R, Jfri A, Assaf C. The Landscape of Cutaneous T-Cell Lymphoma (CTCL) in the Middle East and North Africa (MENA) and the Establishment of the MENA CTCL Working Group. Cancers. 16(19):3380.

• Klüssendorf M, Pervaiz S, Stauber T. Monitoring leucine-rich repeat containing 8 channel (LRRC8/VRAC) activity using sensitized-emission Förster resonance energy transfer (SE-FRET). J Vis Exp, 210:e66953.
• He H, Cao X, He F, Zhang W, Wang X, Peng P, Xie C, Yin F, Li D, Li J, Wang M, Klüssendorf M, Jentsch TJ, Stauber T*, Peng J*. Mutations in CLCN6 as a novel genetic cause of neuronal ceroid lipofuscinosis in patients and a murine model. Ann Neurol, 96:608-624. *equal contribution, corresponding authors
• Polovitskaya MM, Rana T, Ullrich K, Murko S, Bierhals T, Vogt G, Stauber T, Kubisch C, Santer R, Jentsch TJ. Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease. J Biol Chem, 300:107437.
• Kashyap P, Bertelli S, Cao F, Kostritskaia Y, Blank F, Srikanth NA, Schlack-Leigers C, Saleppico R, Bierhuizen D, Lu X, Nickel W, Campbell RE, Plested AJR, Stauber T, Taylor MJ, Ewers H. An optogenetic method for the controlled release of single molecules. Nat Methods, 21:666-672.
• Morgenstern E, Molthof C, Schwartz U, Graf J, Bruckmann A, Hombach S, Kretz M. lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation. Life Sci. Alliance, 7 (7).
• Hansen-Abeck I, Geidel G, Abeck F, Kött J, Cankaya R, Dobos G, Mitteldorf C, Nicolay JP, Albrecht JD, Menzer C, Livingstone E, Mengoni M, Braun AD, Wobser M, Klemke CD, Tratzmiller S, Assaf C, Terheyden P, Klespe KC, Schneider SW, Booken N. Pegylated interferon-α2a in cutaneous T-cell lymphoma - a multicenter retrospective data analysis with 70 patients. J Dtsch Dermatol Ges. 2024 Oct 2. doi: 10.1111/ddg.15511. Online ahead of print.
• Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, López-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Böddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kühn R, Wanker EE, Priller J, Metzger JJ, Prigione A. Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PMID: 39174523; PMCID: PMC11341898.
• Houge G, Bratland E, Aukrust I, Tveten K, Žukauskaitė G, Sansovic I, Brea-Fernández AJ, Mayer K, Paakkola T, McKenna C, Wright W, Markovic MK, Lildballe DL, Konecny M, Smol T, Alhopuro P, Gouttenoire EA, Obeid K, Todorova A, Jankovic M, Lubieniecka JM, Stojiljkovic M, Buisine MP, Haukanes BI, Lorans M, Roomere H, Petit FM, Haanpää MK, Beneteau C, Pérez B, Plaseska-Karanfilska D, Rath M, Fuhrmann N, Ferreira BI, Stephanou C, Sjursen W, Maver A, Rouzier C, Chirita-Emandi A, Gonçalves J, Kuek WCD, Broly M, Haer-Wigman L, Thong MK, Tae SK, Hyblova M, den Dunnen JT, Laner A. Comparison of the ABC and ACMG systems for variant classification. Eur J Hum Genet. 2024 Jul;32(7):858-863. doi: 10.1038/s41431-024-01617-8.
• Zaninetti C, Rivera J, Vater L, Ohlenforst S, Leinøe E, Böckelmann D, Freson K, Thiele T, Makhloufi H, Rath M, Eberl W, Wolff M, Freyer C, Wesche J, Zieger B, Felbor U, Heidel FH, Greinacher A. Aggregates of nonmuscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia. J Thromb Haemost. 2024 Apr;22(4):1179-1186. doi: 10.1016/j.jtha.2023.12.007.
• Oymanns M, Daum-Marzian M, Assaf C. Mogamulizumab and Concomitant Hypofractionated Low-Dose Total Skin Electron Beam Therapy (2 × 4 Gy) in Cutaneous T-Cell Lymphoma: Proof of Principle, Report of Two Cases. Curr Oncol. 2024 Sep 13;31(9):5412-5421. doi: 10.3390/curroncol31090400.
• Melchers S, Roemer M, Albrecht JD, Assaf C, von Gugelberg C, Guenova E, Klemke CD, Moritz RKC, Schlaak M, Stadler R, Wehkamp U, Wobser M, Albrecht T, Goerdt S, Schneider S, Nicolay JP. Evaluation of Sézary cell marker expression and cell death behaviour upon in vitro treatment by flow cytometry in Sézary syndrome patients. Exp Dermatol. 2024 Sep;33(9):e15171. doi: 10.1111/exd.15171.
• Vahabi SM, Bahramian S, Esmaeili F, Danaei B, Kalantari Y, Fazeli P, Sadeghi S, Hajizadeh N, Assaf C, Etesami I. JAK Inhibitors in Cutaneous T-Cell Lymphoma: Friend or Foe? A Systematic Review of the Published Literature. Cancers. 2024 Feb 21;16(5):861. doi: 10.3390/cancers16050861.
• Zifarelli G, Pusch M, Stauber T. Editorial: Intracellular ion channels in health and disease. Front Pharmacol, 15:1430150.
• Zhao G, Zhang HM, Nasseri AR, Yip F, Telkar N, Chen YT, Aghakeshmiri S, Küper C, Lam W, Yang W, Zhao J, Luo H, McManus BN, Yang D. Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis. Basic Res Cardiol. 2024 Jun 5. doi: 10.1007/s00395-024-01058-w.
• Glitsch MD. Recent advances in acid sensing by G protein coupled receptors. Pflugers Arch. 2024, 476: 445-465, doi: 10.1007/s00424-024-02919-y
• Weigelt J, Petrosyan M, Oliveira-Ferrer L, Schmalfeldt B, Bartmann C, Dietl J, Stürken C and Schumacher U. Ovarian cancer cells regulate their mitochondrial content and high mitochondrial content is associated with a poor prognosis. BMC Cancer. 2024 Jan 8;24(1):43. doi: 10.1186/s12885-023-11667-8.

2023

• Bose S, de Heus C, Kennedy ME, Wang F, Jentsch TJ, Klumperman J, Stauber T. Impaired autophagic clearance with a gain-of-function variant of the lysosomal Cl-/H+ exchanger ClC-7. Biomolecules, 13:1799.
• Morgenstern E, Kretz M. The human long non-coding RNA LINC00941 and its modes of action in health and disease. Biol Chem, 404:1025-1036.
• Stauber T, Wartosch L, Vishnolia S, Schulz A, Kornak U. CLCN7, a gene shared by autosomal recessive and autosomal dominant osteopetrosis. Bone 168:116639.
• Pilz RA, Skowronek D, Mellinger L, Bekeschus S, Felbor U, Rath M. Endothelial Differentiation of CCM1 Knockout iPSCs Triggers the Establishment of a Specific Gene Expression Signature. Int J Mol Sci. 2023 Feb 16;24(4):3993. doi: 10.3390/ijms24043993.
• He H, Zhang H, Chen H, Yin F, Stauber T, Zou X, Peng J. Functional analysis of two SLC9A6 frameshift variants in lymphoblastoid cells from patients with Christianson syndrome. CNS Neurosc Ther, 29:4059-4069.
• Webster JF, Beerens S, Wozny C. Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula. Neuropsychopharmacology. 2023 Apr;48(5):745-753. doi: 10.1038/s41386-022-01493-0.
• Liu T, Li Y, Wang D, Stauber T, Zhao J. Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022. Front Pharmacol, 14:1234885.
• Kostritskaia Y, Klüssendorf M, Pan YE, Hassani Nia F, Kostova S, Stauber T. Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206. In Fahlke C (ed) Anion Channels and Transporters in book series Handb Exp Pharmacol 283:181-218.
• Ninosu N, Melchers S, Kappenstein M, Booken N, Hansen I, Blanchard M, Guenova E, Assaf C, Goerdt S, Nicolay JP. Mogamulizumab Combined with Extracorporeal Photopheresis as a Novel Therapy in Erythrodermic Cutaneous T-cell Lymphoma. Cancers. 2023 Dec 27;16(1):141. doi: 10.3390/cancers16010141.
• Assaf C, Illidge TM, Waser N, He M, Li T, Zomas A, Bent-Ennakhil N, Little M, Ortiz-Romero PL, Pimpinelli N, Dalal M, Bagot M. A Retrospective Chart Review of Treatment Patterns and Overall Survival among a Cohort of Patients with Relapsed/Refractory Mycosis Fungoides in France, Germany, Italy, Spain and the United Kingdom. Cancers. 2023 Nov 30;15(23):5669. doi: 10.3390/cancers15235669.
• Latzka J, Assaf C, Bagot M, Cozzio A, Dummer R, Guenova E, Gniadecki R, Hodak E, Jonak C, Klemke CD, Knobler R, Morrris S, Nicolay JP, Ortiz-Romero PL, Papadavid E, Pimpinelli N, Quaglino P, Ranki A, Scarisbrick J, Stadler R, Väkevä L, Vermeer MH, Wehkamp U, Whittaker S, Willemze R, Trautinger F. EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2023. Eur J Cancer. 2023 Dec;195:113343. doi: 10.1016/j.ejca.2023.113343.
• Assaf C, Dobos G, Zech IM, Doess A, May M, Jadasz J. Epidemiology of mature T/NK-cell lymphomas in Germany - A representative cross-sectional study based on SHI claims data. J Dtsch Dermatol Ges. 2023 Nov;21(11):1320-1327. doi: 10.1111/ddg.15187. Epub 2023 Oct 16.
• Nicolay JP, Melchers S, Albrecht JD, Assaf C, Dippel E, Stadler R, Wehkamp U, Wobser M, Zhao J, Burghaus I, Schneider S, Gülow K, Goerdt S, Schürch CM, Utikal JS, Krammer PH. Dimethyl fumarate treatment in relapsed and refractory cutaneous T-cell lymphoma: a multicenter phase 2 study. Blood. 2023 Aug 31;142(9):794-805. doi: 10.1182/
• Assaf C, Querfeld C, Scandurra M, Turini M, Scarisbrick JJ. Prior Bexarotene or Phototherapy Does Not Affect Response to Chlormethine Gel: Post Hoc Analysis of a Pivotal Trial. Acta Derm Venereol. 2023 Feb 7;103:adv00862. doi: 10.2340/actadv.v103.4881.
• Oymanns M, Daum-Marzian M, Bellm A, Elsayad K, Eich HT, Assaf C. Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced cutaneous T-cell lymphoma. Br J Dermatol. 2023 Jan 23;188(1):145-146. doi: 10.1093/bjd/ljac012.
• Hadrian K, Musial G, Schönberg A, Georgiev T, Küper C, Bock F, Jantsch J; Claus Cursiefen C, Eming SA, Hos D: “The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury”. Exp Mol Med. 2023 Mar;55(3):565-573. doi: 10.1038/s12276-023-00954-w.  
• Reimer F, Bryan S, Legler K, Karn T, Eppenberger-Castori S, Matschke J, Pereira-Veiga T, Wikman H, Witzel I, Müller V, Schmalfeldt B, Milde-Langosch K, Schumacher U, Stürken C, Oliveira-Ferrer L. The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients. Cancer Cell Int. 2023 Mar 16;23(1):47. doi: 10.1186/s12935-023-02896-9. Last author Stürken /Oliveira- Ferrer    
• Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C,  Milde-Langosch K, Oliveira-Ferrer L, Ricklefs FL, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnen-berger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T.  Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo. J Hematol Oncol. 2023 Mar 17;16(1):23. doi: 10.1186/s13045-023-01413-9.       

2022

• Skowronek D, Pilz RA, Bonde L, Schamuhn OJ, Feldmann JL, Hoffjan S, Much CD, Felbor U, Rath M. Cas9-Mediated Nanopore Sequencing Enables Precise Characterization of Structural Variants in CCM Genes. Int J Mol Sci. 2022 Dec 9;23(24):15639. doi: 10.3390/ijms232415639.
• Hamester F, Stürken C, Legler K, Eylmann K, Möller K, Roßberg M, Gorzelanny C, Bauer AT, Windhorst S, Schmalfeldt B, Laakmann E, Müller V, Witzel I, Oliveira-Ferrer L. `Key Role of Hyaluronan Metabolism for the Develop-ment of Brain Metastases in Triple-Negative Breast Cancer.` Cells. 2022 Oct 18;11(20):3275. doi: 10.3390/cells11203275.    
• Oliveira-Ferrer L, Schmalfeldt B, Dietl J, Bartmann C, Schumacher U, Stürken C. Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients. Biomedicines. 2022 Nov 16;10(11):2944. doi: 10.3390/biomedicines10112944.
• Kuntz T, Siebdrath J, Hofmann SC, Baltaci M, Schaller J, Hellmich M, von Goltzheim LS, Assaf C, Oellig F, Michalowitz AL, Helbig D, Kreuter A. Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers. J Dtsch Dermatol Ges. 2022 Nov 28. doi: 10.1111/ddg.14911. Online ahead of print.
• Michalowitz AL, Burmann SN, Oellig F, Assaf C, Cerroni L, Kreuter A.Bendamustine monochemotherapy in aggressive or advanced-stage primary cutaneous T-cell lymphomas. J Eur Acad Dermatol Venereol. 2022 Oct 26. doi: 10.1111/jdv.18691. Online ahead of print.
• Oymanns M, Daum-Marzian M, Bellm A, Elsayad K, Eich HT, Assaf C. Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced CTCL. Br J Dermatol. 2022 Oct 20. doi.org/10.1093/bjd/ljac012
• He H, Stauber T, Liao W, Jiang Y, Yu Y, Peng J. Editorial: Ion channels and transporters in epilepsy: From genes and mechanisms to disease-targeted therapies. Front Mol Neurosci. 2022 Sep 21;15:1011843. doi: 10.3389/fnmol.2022.1011843.
• Langrich T, Bork K, Horstkorte R, Weber V, Hofmann B, Fuszard M, Olzscha H (2022) Disturbance of Key Cellular Subproteomes upon Propofol Treatment Is Associated with Increased Permeability of the Blood-Brain Barrier. Proteomes. doi: 10.3390/proteomes10030028.
  Blazejak C, Stranzenbach R, Gosman J, Gambichler T, Wehkamp U, Stendel S, Klemke CD, Wobser M, Olk J, Nicolay JP, Weyermann M, Stadler R, Assaf C. Clinical Outcomes of Advanced-Stage Cutaneous Lymphoma under Low-Dose Gemcitabine Treatment: Real-Life Data from the German Cutaneous Lymphoma Network. Dermatology. 2022;238(3):498-506.
• Querfeld C, Scarisbrick JJ, Assaf C, Guenova E, Bagot M, Ortiz-Romero PL, Quaglino P, Bonizzoni E, Hodak E. Post hoc Analysis of a Randomized, Controlled, Phase 2 Study to Assess Response Rates with Chlormethine/Mechlorethamine Gel in Patients with Stage IA-IIA Mycosis Fungoides. Dermatology. 2022;238(2):347-357
• Assaf C, Dobos G. New treatment concepts and combination therapies for cutaneous T-cell lymphomas Dermatologie (Heidelb). 2022 Sep 8. doi: 10.1007/s00105-022-05053-x.
• Model MA, Hassani Nia F, Zook E, Hollembeak JE, Stauber T. Uptake of Fluorescein upon Osmotic Cell Swelling is Dependent on the Volume-Regulated Anion Channel VRAC/LRRC8. PPExMed 2022;1:3-14. doi: 10.33594/000000533.
• Assaf C, Dobos G, Zech IM, Doess A, Hibbe T, Jadasz JJ. Care structure of patients with mycosis fungoides and Sézary syndrome in Germany - Care research based on SHI claims data. J Dtsch Dermatol Ges. 2022 May;20(5):643-651. doi: 10.1111/ddg.14725.
• Assaf C, Booken N, Dippel E, Guenova E, Jonak C, Klemke CD, Nicolay JP, Schlaak M, Wobser M, Trautinger F. The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region). J Dtsch Dermatol Ges. 2022 May;20(5):579-586. doi: 10.1111/ddg.14688.
• Beerens S, Winterer J, Lukacsovich D, Földy C, Wozny C. Transcriptomically-Guided Pharmacological Experiments in Neocortical and Hippocampal NPY-Positive GABAergic Interneurons. eNeuro. 2022 Apr 25;9(2):ENEURO.0005-22.2022. doi: 10.1523/ENEURO.0005-22.2022.
• Dippel E, Assaf C, Becker JC, von Bergwelt-Baildon M, Bernreiter S, Cozzio A, Eich HT, Elsayad K, Follmann M, Grabbe S, Hillen U, Klapper W, Klemke CD, Loquai C, Meiss F, Mitteldorf C, Wehkamp U, Nashan D, Nicolay JP, Oschlies I, Schlaak M, Stranzenbach R, Moritz R, Stoll C, Vag T, Weichenthal M, Wobser M, Stadler R. S2k-Guidelines - Cutaneous lymphomas (ICD10 C82 - C86): Update 2021. J Dtsch Dermatol Ges. 2022 Apr;20(4):537-554.
• Nawar T, Elsayad K, Müller EC, Rolf D, Moritz RKC, Bormann E, Weishaupt C, Stranzenbach R, Stadler R, Moustakis C, Assaf C, Livingstone E, Sunderkötter C, Steinbrink K, Eich HT. Quality of life in patients with mycosis fungoides and Sézary syndrome undergoing low-dose total skin electron beam therapy with or without maintenance therapy. J Am Acad Dermatol. 2022 Apr;86(4):889-891
• Dobos G, Assaf C. Transcriptomic changes during stage progression of mycosis fungoides: from translational analyses to their potential clinical implications. Br J Dermatol. 2022 Mar;186(3):387-388
• Moudio S, Willis A, Pytka K, Abulkassim R, Brett RR, Webster JF, Wozny C, Barbour M, Jiang HR, Watson DG, van Kralingen JC, MacKenzie SM, Daniels M, McColl BW, Sossick S, Nuthall HN, Bushell TJ. Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology (Berl). 2022 Jan;239(1):229-242. doi: 10.1007/s00213-021-06040-1.

2021

• Chen L, Hassani Nia F, Stauber T. Ion Channels and Transporters in Muscle Cell Differentiation. Int J Mol Sci. 2021 Dec 19;22(24):13615. doi: 10.3390/ijms222413615.
• Assaf C, Waser N, Bagot M, He M, Li T, Dalal M, Gavini F, Trinchese F, Zomas A, Little M, Pimpinelli N, Ortiz-Romero PL, Illidge TM. Contemporary Treatment Patterns and Response in Relapsed/Refractory Cutaneous T-Cell Lymphoma (CTCL) across Five European Countries. Cancers 2021 Dec 29;14(1):145.
• Webster JF, Lecca S, Wozny C. Inhibition Within the Lateral Habenula-Implications for Affective Disorders. Front Behav Neurosci. 2021 Nov 26;15:786011. doi: 10.3389/fnbeh.2021.786011. PMID: 34899206.
• Kolobkova Y, Pervaiz S, Stauber T. The expanding toolbox to study the LRRC8-formed volume-regulated anion channel VRAC. Curr Top Membr. 2021;88:119-163. doi: 10.1016/bs.ctm.2021.10.001.
• Pfirrmann T, Chondrogianni N, Olzscha H, Vasilaki A. Editorial: Dysregulated Protein Homeostasis in the Aging Organism. Front Mol Biosci. 2021 Oct 14;8:788118. doi: 10.3389/fmolb.2021.788118.
• Zimmer L, Livingstone E, Krackhardt A, Schultz ES, Göppner D, Assaf C, Trebing D, Stelter K, Windemuth-Kieselbach C, Ugurel S, Schadendorf D. Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAFV600 mutant melanoma: safety and tolerability results from the phase I IMMU-TARGET trial. Eur J Cancer. 2021 Oct 13;158:72-84
• Liang HC, Costanza M, Prutsch N, …, Assaf C, Knörr F, Damm-Welk C, Woessmann W, Turner SD, Look AT, Mathas S, Kenner L, Merkel O. Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nat Commun. 2021 Sep 22;12(1):5577
• Rössler U, Hennig AF, Stelzer N, Bose S, Kopp J, Søe K, Cyganek L, Zifarelli G, Ali S, von der Hagen M, Strässler ET, Hahn G, Pusch M, Stauber T, Izsvák Z, Gossen M, Stachelscheid H, Kornak U. Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis. J Bone Miner Res. 2021 Aug;36(8):1621-1635. doi: 10.1002/jbmr.4322.
• Beerens S, Vroman R, Webster JF, Wozny C. Probing subicular inputs to the medial prefrontal cortex. iScience. 2021 Jul 10;24(8):102856. doi: 10.1016/j.isci.2021.102856.
• He H, Guzman RE, Cao D, Sierra-Marquez J, Yin F, Fahlke C, Peng J, Stauber T. The molecular and phenotypic spectrum of CLCN4-related epilepsy. Epilepsia. 2021 Jun;62(6):1401-1415. doi: 10.1111/epi.16906.
• Webster JF, Vroman R, Beerens S, Sakata S, Wozny C. NDNF is selectively expressed by neocortical, but not habenular neurogliaform cells. Eur J Neurosci. 2021 Jun;53(11):3561-3575. doi: 10.1111/ejn.15237.
• He H, Cao X, Yin F, Wu T, Stauber T, Peng J. West Syndrome Caused By a Chloride/Proton Exchange-Uncoupling CLCN6 Mutation Related to Autophagic-Lysosomal Dysfunction. Mol Neurobiol. 2021 Jun;58(6):2990-2999. doi: 10.1007/s12035-021-02291-3.
• Riemer J, Panfilova D, Olzscha H. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases. Proteostasis and Proteolysis, CRC Press, 2021, 276 pp.
• Assaf C. Cancer-Associated Fibroblasts Play an Important Role in Early-Stage Mycosis Fungoides. J Invest Dermatol. 2021 Mar;141(3):479-480
• Bose S, He H, Stauber T. Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters. Front Cell Dev Biol. 2021 Feb 23;9:639231. doi: 10.3389/fcell.2021.639231.
• Wehkamp U, Mitteldorf C, Stendel S, Stranzenbach R, Nicolay JP, Wobser M, Weichenthal M, Schneiderbauer R, Klemke CD, Hillen U, Kempf W, Assaf C. Most rare subtypes of cutaneous lymphoma display variable CD30 expression: analysis of the German Cutaneous Lymphoma Network. Br J Dermatol. 2021 Jan 22. doi: 10.1111/bjd.19823.

2020

• Yuste R, …, Wozny C, Wuttke TV, Yong L, Yuan J, Zeng H, Lein E. A community-based transcriptomics classification and nomenclature of neocortical cell types. Nat Neurosci. 2020 Dec;23(12):1456-1468. doi: 10.1038/s41593-020-0685-8.
• Weber V, Olzscha H, Längrich T, Hartmann C, Jung M, Hofmann B, Horstkorte R, Bork K. Glycation Increases the Risk of Microbial Traversal through an Endothelial Model of the Human Blood-Brain Barrier after Use of Anesthetics. J Clin Med. 2020 Nov 16;9(11):3672. doi: 10.3390/jcm9113672.
• Chen L, König B, Stauber T. LRRC8 channel activation and reduction in cytosolic chloride concentration during early differentiation of C2C12 myoblasts. Biochem Biophys Res Commun. 2020 Nov 12;532(3):482-488. doi: 10.1016/j.bbrc.2020.08.080.
• Knobler R, Arenberger P, Arun A, Assaf C, Bagot M, Berlin G, Bohbot A, Calzavara-Pinton P, Child F, et al. European dermatology forum - updated guidelines on the use of extracorporeal photopheresis 2020 - part 1. J Eur Acad Dermatol Venereol. 2020 Oct 6. doi: 10.1111/jdv.16890. Online ahead of print
• Knobler R, Arenberger P, Arun A, Assaf C, Bagot M, Berlin G, Bohbot A, Calzavara-Pinton P, Child F, et al. European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2. J Eur Acad Dermatol Venereol. 2020 Sep 22. doi: 10.1111/jdv.16889. Online ahead of print
• Kulka LAM, Fangmann PV, Panfilova D, Olzscha H. Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease. Front Cell Dev Biol. 2020 Jun 3;8:425. doi: 10.3389/fcell.2020.00425.
• Glitsch MD. Helix 8 - Putting a spring in mechano-sensing. Cell Calcium. 2020 May;87:102192. doi: 10.1016/j.ceca.2020.102192.
• Weber V, Bork K, Horstkorte R, Olzscha H. Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells. J Vis Exp. 2020 Feb 14;(156). doi: 10.3791/60692.
• Elsayad K, Kroeger K, Greve B, Moustakis C, Assaf C, Stadler R, Lenz G, Weishaupt C, Eich HT, et al. Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlenther Onkol. 2020 Jan;196(1):77-84.

2019

• Pervaiz S, Kopp A, von Kleist L and Stauber T (2019) Absolute protein amounts and relative abundance of volume-regulated anion channel (VRAC) LRRC8 subunits in cells and tissues revealed by quantitative immunoblotting. Int J Mol Sci E5879.
• Astaburuaga R, Quintanar Haro OD, Stauber T^*, Relógio A^* (2019) A mathematical model of lysosomal ion homeostasis points to differential effects of Cl^- transport in Ca²⁺ dynamics. Cells E1263. ^*corresponding authors